Numbering Code	G-ENG06 5G206 LE51	Year/Term	2022 ・ First semester
Number of Credits	2	Course Type	Lecture
Target Year		Target Student
Language	English	Day/Period	Tue.3
Instructor name	YOKOKAWA RYUUJI (Graduate School of Engineering Professor) KAMEI KENICHIROU (Institute for Advanced Study Associate Professor)
Outline and Purpose of the Course	Micro/nano systems are based on micro/nano fabrications and encompasses not only individual phenomena in physics and chemistry but also the integrated phenomena observed in these fields. Moreover, recently the integrated systems utilizing biomaterials (cells, tissues, organs etc.) are being developed to realize micro/nano bio systems with potential applications in medicine, drug development, and basic studies in life sciences. In this course, we focus on the difference of physical and chemical phenomena between micro/nano and micro scales. Micro/nano fabrications for micro/nano biosystems, biomolecular sensing, DNA/protein/cell manipulation and their integration to realize complex integrated biosystems such as BioMEMS and MicroTAS will be introduced.
Course Goals	To understand the fundamentals of fabrication technologies for BioMEMS and MicroTAS. To understand the roles of micro/nano fabrications in life sciences. To understand sensing and actuation mechanisms at micro/nano scales.
Schedule and Contents	The specific course goals are as outlined below. Week 1-3: Introduction for micro/bio systems - Introduce the history and fundamentals of BioMEMS and MicroTAS based on micro/nano fabrications. Week 4-7: Soft micro machining - In micro/bio systems, biomaterials and organic/inorganic polymers are used as structural materials. Fabrication of these materials by the so-called “soft micromachining”, and their applications will be described. Week 8-9: Micro/nano scale bio materials - Integration of functional biomolecules, cells and polymer materials to realize micro/bio systems are described. Week 10-11: Micro Total Analysis Systems (MicroTAS) - On-chip chemical analysis systems and bio sensing devices are described. Week 12-15: Nano bio systems - Integration of micro/nano fabrications and biomaterials for application to biomedical and regenerative medicine are described.
Evaluation Methods and Policy	Evaluation will be based on assignments and class performance. Evaluation for class performance includes attendance and reports given at class.
Course Requirements	The course is based on micro/nano fabrication described in Microfabrication (10G203). It is highly recommended to register for the course as well.
Study outside of Class (preparation and review)	Preparation and review of course materials are necessary.