Numbering Code	U-PHA00 2C305 LJ86	Year/Term	2022 ・ First semester
Number of Credits	2	Course Type	Lecture
Target Year	2nd & 3rd year students	Target Student
Language	Japanese	Day/Period	Tue.2
Instructor name	KANEKO SHIYUUJI (Graduate School of Pharmaceutical Sciences Professor)
Outline and Purpose of the Course	The biomolecules targeted by drugs in the body are either receptors, enzymes, membrane-transport proteins, or transcription factors. We will understand these functional proteins, together with endogenous ligands (physiologically active substances) and the intracellular signal-transduction system that provides the basis for pharmacology. The purpose of these lectures is to understand the complex information networks that these biomolecules build at the cellular level, the mechanisms that control organ and cell functions, and the ways in which they malfunction in major pathological conditions.
Course Goals	1. Explain the theory behind drugs binding to and interacting with target biomolecules. 2. Explain the biomolecules discovered as drug-discovery targets and possible future developments. 3. Explain the types, classifications, and functions of physiologically active substances that exist in the living body. 4. Explain the distribution of target molecules that bioactive substances act on in living organisms, as well as the intracellular-signal-transduction system. 5. Explain the basic principles of membrane potential changes and substance metabolism used for intracellular signal transduction. 6. Explain the disruption of cell function and the mechanism of drug treatment in pathological conditions.
Schedule and Contents	The lesson plan also shows the relevant textbook pages. 1. Guidance: Flipped classroom explanation and trial, drug receptor theory (pp. 4?16) 2. Membrane potential and action potential, voltage-gated Na + / K + channels (pp. 79?85) 3. Synaptic transmission and muscle contraction, Ca2 + channel (pp. 74?79) 4. Transporters, transcellular transportation (pp. 86?94) 5. G protein-coupled receptors, intracellular signal transduction (pp. 49?56) 6. Receptor kinases, nuclear receptors (pp. 57?69) 7. Summary of the first half and notebook evaluation 8. Mid-term exam 9. Inhibitory amino acids (pp. 96?109) 10. Excitatory amino acids (pp. 109?115) 11. Acetylcholine (pp. 116?124), nitric oxide (pp. 193?195) 12. Catecoramine (pp. 125?139) 13. Serotonin (pp. 140?150), neuropeptide (pp. 164?172) 14. Histamine, nucleotides (pp. 151?163) 15. Overall summary and exercises
Evaluation Methods and Policy	The evaluation is based on the following: small tests based on prior self-study 10%; a mid-term exam 40%; and regular tests 50%. The small tests will be conducted using PandA at the start of lectures. The mid-term exam includes five questions, four of which are multiple-choice; the regular tests include five free-answer questions.
Course Requirements	None
Study outside of Class (preparation and review)	This subject follows the “flipped classroom” method. Make sure to prepare before each lesson, except for the very first one, by watching the YouTube videos. The printouts required for preparatory study will be distributed during the previous lesson. Be sure to have your computer and smartphone ready during class, and first perform a confirmation test on the PandA page. You will then be given exercises, so please check the textbooks and the Internet and write the information in a notebook to organize it.
Textbooks	Textbooks/References	田中／加藤／成宮 『NEW薬理学（改訂第7版）』 (Nankoudou) ISBN:978-4-524-26175-8 These textbooks are used for the whole pharmacology series (I, II, and III)
References, etc.	D.E.Golan et al. 『Principles of Pharmacology 4th Edition』 (Wolters Kluwer) ISBN:978-1-45119-100-4 Kindle version, graphs will be handed out, L.L.Brunton (Ed.) 『Goodman & Gilman’ｓ Pharmacological Basis of Therapeutics 12th Ed.』 (McGraw-Hill) ISBN:978-0-07-176939-6 Kindle version, graphs will be handed out