生物化学I（物質生化学）【H30以降入学者用】
| Numbering Code | U-PHA00 1C201 LJ86 | Year/Term | 2022 ・ Second semester | |
|---|---|---|---|---|
| Number of Credits | 2 | Course Type | Lecture | |
| Target Year | 1st year students or above | Target Student | ||
| Language | Japanese | Day/Period | Thu.1 | |
| Instructor name | KAKIZAWA SHO (Graduate School of Pharmaceutical Sciences Associate Professor) | |||
| Outline and Purpose of the Course | Biochemistry elucidates life phenomena through chemical means. It is a discipline that investigates what substances the living body is composed of, how these substances are synthesized and decomposed, what properties the substances have, and what functions they perform within the body. In this lecture, we will study the basic concepts of biochemistry and the properties of major biological components. | |||
| Course Goals |
1. Explain basic concepts related to the structure, properties, and roles played by molecules responsible for biological phenomena. 2. By taking Biochemistry Training I within Specialized Pharmacy Training 4, students will learn to explain the reaction kinetics and inhibition mechanism of enzymes and become able to make judgements and assessments based on actual measurement results. |
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| Schedule and Contents |
1. Basics of biomaterial chemistry (introductory lecture) 2. Physicochemical properties of water and its role in living organisms 3. Characteristics of amino acids and their relationship with peptides and proteins 4. Relationship between the higher-order structure and the function of proteins 5. Biological significance of protein-ligand interaction 6. Enzyme-action mechanism and free energy 7. Enzyme kinetics and inhibition mechanism 8. Classification and structure of monosaccharides 9. Glucoside bonds, the disaccharide/polysaccharide structure, and its role in the living body 10. Nucleotide classification and structure 11. Nucleic-acid structure and function 12. Physicochemical properties and the structure of lipids 13. Physicochemical properties and the structure of biological membranes; mass transport across biological membranes 14. Coupling between bioenergy production and biochemical reactions 15. Summary |
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| Evaluation Methods and Policy | The evaluation will be based on regular written tests. As the evaluation target, students must understand and demonstrate the ability to apply basic knowledge of the structure, properties, and roles of the molecules responsible for biological phenomena described in the attainment targets. | |||
| Course Requirements | None | |||
| Study outside of Class (preparation and review) | Students must strive to deepen their understanding of the lecture content and to reinforce their knowledge by reviewing the content written on the board, their own lecture notes, printouts distributed during lectures, and other materials. | |||
| Textbooks | Textbooks/References | Nelson, Cox, 『レーニンジャーの新生化学： 生化学と分子生物学の基本原理 （第７版） 上巻・下巻』 (Hirokawa Shoten) | ||
| References, etc. | Introduced during class | |||
