Numbering Code	U-PHA00 2A214 LJ86	Year/Term	2022 ・ Second semester
Number of Credits	2	Course Type	Lecture
Target Year	2nd year students or above	Target Student
Language	Japanese	Day/Period	Thu.1
Instructor name	KIMURA IKUO (Graduate School of Biostudies Professor)
Outline and Purpose of the Course	Explain the following concepts related to the structure and function of nucleic acids, which are the chemical basis of gene signaling.
Course Goals	1. Explain the structure and function of nucleic acids. 2. Explain genes and chromosomes. 3. Explain the biosynthesis of DNA, RNA, and proteins. 4. Explain the gene-expression process. 5. Explain the gene-expression-regulation mechanism. 6. Explain the basic technology of genetic modification.
Schedule and Contents	1. Introduction: History of nucleic-acid research 2. Nucleotides and nucleic acids: Types, structures and properties of nucleotides and nucleic acids (DNA, RNA) 3. Genes and chromosomes (1): Chromosome components 4. Genes and chromosomes (2): Structure of genes and chromosomes 5. DNA metabolism (1): DNA replication 6. DNA metabolism (2): DNA mutation and repair 7. DNA metabolism (3): DNA recombination 8. RNA metabolism (1): Transcription from DNA to RNA 9. RNA metabolism (2): RNA processing 10. Protein metabolism (1): Translation from RNA to protein 11. Protein metabolism (2): Post-translational maturation and degradation of proteins 12. Gene-expression regulation (1): The principle of gene-expression regulation 13. Gene-expression regulation (2): The gene-expression-regulation mechanism in bacteria 14. Gene expression regulation (3): The gene expression regulation mechanism in eukaryotes 15. Basics of genetic-engineering technology
Evaluation Methods and Policy	The evaluation will be based on regular written tests, taking into account whether students can discuss nucleic acids, genes, chromosomes, the metabolism of DNA, RNA, and proteins, the gene-expression-regulation mechanism, and the basic technology of DNA recombination in relation to molecular biology, as described in the attainment targets.
Course Requirements	This course assumes a basic knowledge of biochemistry, and students must therefore have already taken Biochemistry I and II.
Study outside of Class (preparation and review)	Lecture printouts will be distributed in advance, so please read them and resolve any doubts you may have about the content. Also, be sure to review the material in order to retain the knowledge of what you have learned.
Textbooks	Textbooks/References	printed handout
References, etc.	ゲノム第4版, , (メディカル・サイエンス・インターナショナル)