Fine Synthetic Chemistry
| Numbering Code | G-ENG16 6H834 LJ60 | Year/Term | 2022 ・ Second semester | |
|---|---|---|---|---|
| Number of Credits | 1.5 | Course Type | Lecture | |
| Target Year | Target Student | |||
| Language | Japanese | Day/Period | Wed.2 | |
| Instructor name | ISHIDA NAOKI (Graduate School of Engineering Associate Professor) | |||
| Schedule and Contents |
principle and examples of selective reaction,4times,1. Hammond Postulate and Curtin-Hammett Principle 2. Chemo- and Stereoselectivities of Hydride Reduction 3. Cram Model and Felkin-Anh Model (Basic Rule) 4. Cram Model and Felkin-Anh Model (Application) total synthesis of natural products,6times,5. (+)-Himbacine (Chackalamannil 1999) (key point: Diels-Alder) 6. ZK-EPO (Schering AG 2006) (key point: Macrolactonization) 7. (-)-Dactylolide (McLeod 2006) (key point: Ireland-Claisen) 8. (-)-Scopadulcic Acid (Overman 1999) (key point: Heck Reaction) 9. (+)-Paniculatine (Sha 1999) (key point: Radical Cyclization) 10. Hirsutine (Tietze 1999) (key point: Domino Reaction) ,1time,11. Confirmation of achievement degree: The synthesis of target molecules using selective reaction is proposed by students, and then, we discuss it. ,, |
|||
| Evaluation Methods and Policy | Paper test | |||
| Course Requirements | None | |||
| Textbooks | Textbooks/References | nothing | ||
| References, etc. | Organic Synthesis Workbook II (Wiley-VCH), Organic Synthesis Workbook III (Wiley-VCH) | |||
| Related URL | ||||
