Research in Systems Biology & Drug Dicovery
| Numbering Code | G-PHA02 75301 SJ86 | Year/Term | 2022 ・ Irregular, year-round | |
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| Number of Credits | 4 | Course Type | Seminar | |
| Target Year | 1st and 2nd year master's students | Target Student | ||
| Language | Japanese | Day/Period | ||
| Instructor name |
OHNO HIROAKI (Graduate School of Pharmaceutical Sciences Professor) KAKEYA HIDEAKI (Graduate School of Pharmaceutical Sciences Professor) DOI MASAO (Institute for Liberal Arts and Sciences Professor) HIRASAWA AKIRA (Graduate School of Pharmaceutical Sciences Associate Professor) HATTORI AKIRA (Graduate School of Pharmaceutical Sciences Associate Professor) INUKI SHINSUKE (Graduate School of Pharmaceutical Sciences Associate Professor) YAMAGUCHI YOSHIAKI (Graduate School of Pharmaceutical Sciences Senior Lecturer) |
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| Outline and Purpose of the Course | This course offers research, seminars, and practical training leadership in the fields of systems biology and drug discovery. | |||
| Course Goals |
To develop the ability to explain the importance of comprehensive analysis techniques in pharmacological evaluations. To develop the ability to understand applied research in the drug discovery of G protein-coupled receptors. To develop the ability to explain the functions from the action mechanisms and 3D structure of receptors. To develop the ability to explain the basic matters pertaining to chemoinformatics, bioinformatics, and chemical biology. To develop the ability to explain biorhythm and give examples of timed drug discovery research that uses it. To develop the ability to understand the fundamental importance of molecular design in drug discovery lead compounds. To develop the ability to explain the importance of natural products chemistry and natural products research from searches for natural products. |
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| Schedule and Contents |
Each of the following subjects is intended to account for 2 weeks of classes: ・Research in the preclinical field of drug discovery through the practice of pharmacological evaluations using comprehensive analysis techniques (Akira Hirasawa) ・Ligand search research based on the genomic function science of G protein-coupled receptors (Akira Hirasawa) ・Applied research in drug discovery from the genomic function science of G protein-coupled receptors (Akira Hirasawa) ・Analytical research of receptor functions in organisms (Akira Hirasawa) ・Research on the 3D structures and action mechanisms of receptor proteins (Shinya Oishi & Hiroaki Ohno) ・Clarify the molecular recognition mechanisms of drug-receptors through bioinformatics (Akira Hattori & Hideyaki Kakeya) ・Clarify the mechanisms of time generation and tuning in mammalian biological rhythms (Masao Doi & Yoshiaki Yamaguchi) ・Time drug discovery research (Masao Doi & Yoshiaki Yamaguchi) ・Drug discovery research from clarification of the operating principles of the multilayer molecular network systems of mammalian biorhythms (Masao Doi & Yoshiaki Yamaguchi) ・Advanced chemical biological research aimed at developing next-generation chemotherapy for multifactorial diseases (Hideyaki Kakeya & Akira Hattori) ・System chemotherapy research utilizing chemoinformatics and bioinformatics (Hideyaki Kakeya & Akira Hattori) ・Development of a useful substance production and discovery process through genetic engineering methods (Hiroaki Ohno & Shinya Oishi) ・Development of molecular design and chemical synthesis technologies for pharmaceutical leads with new skeletons (Hiroaki Ohno & Shinya Oishi) ・Research on the construction and application of evaluation systems for the bioactivity of drug candidate compounds (Hiroaki Ohno & Shinya Oishi) ・Natural product chemistry and natural product pharmaceutical research on new bioactive substances aimed at developing lead compounds in drug discovery (Hideyaki Kakeya & Akira Hattori) |
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| Evaluation Methods and Policy | Students will be comprehensively evaluated based on subject reports. Evaluation may also be based on class attendance and practice. | |||
| Course Requirements | None | |||
| Study outside of Class (preparation and review) | Students should prepare for class and review any distributed printouts to improve their understanding. | |||
| Textbooks | Textbooks/References | Others; printouts will be distributed where appropriate. | ||
| References, etc. | Others; may be specified according to seminar content. | |||
