Research in Basic Fine Organic Synthesis
| Numbering Code | G-PHA01 73209 EJ86 | Year/Term | 2022 ・ Irregular, year-round | |
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| Number of Credits | 4 | Course Type | Experiment | |
| Target Year | 1st and 2nd year master's students | Target Student | ||
| Language | Japanese | Day/Period | ||
| Instructor name |
OHMIYA HIROHISA (Institute for Chemical Research Professor) YOSHIHIRO UEDA (Institute for Chemical Research Assistant Professor) |
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| Outline and Purpose of the Course |
(Aim) The interactions and reactions of organic molecules could be said to be communication between molecules. This course aims to improve understanding of the language used in this context in order to develop a pioneering reaction control system and pave the way toward new concept proposals and research fields in organic chemistry. (Summary) Research on the establishment of dynamic asymmetric control methodologies, the development of selective reaction catalysts based on dynamic molecular recognition, the development of molecular recognition-type catalysts that react at a specific point of a polyfunctional compound, and substrate specificity design, specifically: the development of catalysts that identify and react to the absolute configuration and shape of molecules, the discovery of new molecular species with unique structures, the construction of higher-order structures based on the accumulation effect of chiral units, the total synthesis of bioactive natural products based on non-classical retrosynthetic analysis, the creation of new reaction and recognition fields, the development of functional molecules, the development of remote asymmetric induction methods, and the development of asymmetric synthesis methods for supramolecules. |
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| Course Goals |
(1) Devise target molecule synthesis methods and perform experimental synthesis and analysis of the structures and physical properties of synthetic compounds. (2) Evaluation of the performance of reactive catalysts, used to improve catalyst properties. (3) Design and propose new synthetic reactions. (4) Design and propose new molecular recognitions. (5) Design and propose new catalysts. |
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| Schedule and Contents |
1-15: The following experiments will be conducted: ・ Experiments on the new concept of "asymmetric memory" in enolate chemistry ・Experiments on the catalytic regioselective functionalization of saccharides and polyols ・ Experiments on the catalytic asymmetric synthesis of supramolecular catenane and rotaxane ・Experiments on the total synthesis of bioactive natural products based on non-classical retrosynthetic analysis ・ Experiments on the asymmetric synthesis method via short-lived chiral enolates ・ Experiments on improving the longevity of chiral enolates ・ Experiments on remote asymmetric induction ・ Experiments to develop asymmetric synthesis methods using organic catalysts ・ Experiments on the synthesis of new amino acids and nitrogen-contain heterocycles with substituted carbon ・ Experiments on the discovery of new axial asymmetric compounds ・ Experiments on enolate chemistry in protic solvents |
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| Evaluation Methods and Policy | Students will be comprehensively evaluated based on their approach to research, their presentations and discussion in research seminars, their conference presentations, and their thesis presentation. | |||
| Course Requirements | None | |||
| Study outside of Class (preparation and review) | Students should thoroughly study and examine experimental methods, reagents, and reaction conditions, etc., using SciFinder and experiment writings. | |||
| Textbooks | Textbooks/References | Not used | ||
| References, etc. | Others; scientific papers, review articles, textbooks, and searches for information on the Internet using e.g. SciFinder. | |||
