Research in Basic Pharmacodynanic Sciences
| Numbering Code | G-PHA01 73208 EJ86 | Year/Term | 2022 ・ Irregular, year-round | |
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| Number of Credits | 4 | Course Type | Experiment | |
| Target Year | 1st and 2nd year master's students | Target Student | ||
| Language | Japanese | Day/Period | ||
| Instructor name |
ONO MASAHIRO (Graduate School of Pharmaceutical Sciences Professor) TAKAKURA YOSHINOBU (Graduate School of Pharmaceutical Sciences Professor) KANEKO SHIYUUJI (Graduate School of Pharmaceutical Sciences Professor) TAKAHASHI YUUKI (Graduate School of Pharmaceutical Sciences Associate Professor) SHIRAKAWA HISASHI (Graduate School of Pharmaceutical Sciences Associate Professor) Hiroyuki Watanabe (Graduate School of Pharmaceutical Sciences Senior Lecturer) |
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| Outline and Purpose of the Course |
(Aim) Through experiments, this course aims to teach students how to approach research and draft research plans, as well as experimental techniques, data sorting methods, and problem-solving skills. (Summary) In this course, students will conduct research on the state analysis of biological functions through molecular imaging and clarify the resultant pathophysiologies and drug interaction mechanisms; students will also conduct research relating to functional nuclear medicine diagnoses based on pathophysiological characteristics, the discovery of therapeutic agents, and the clarification of the effects of organisms in metal-based bioactive compounds. They will conduct biopharmaceutical and pharmacokinetic research into the in vivo kinetics process of nucleic acid drugs used in gene therapy and DNA vaccine therapy and its control mechanisms. Furthermore, they will conduct research into the functional analysis and drug efficacy evaluations of ion channels, transporters, and other membrane transport proteins. |
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| Course Goals |
・To learn the basic experimental techniques needed to conduct research in patho-functional bioanalysis, biopharmaceutical sciences and drug metabolisms, and molecular pharmacology. ・To learn how to approach research and draft research plans, as well as learn data sorting methods and acquire problem-solving skills through experiments. |
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| Schedule and Contents |
1-15: The following experiments will be conducted: ・Experiments on the state analysis of biological functions ・Experiments on the molecular design of bimolecular imaging probes ・ Experiments to clarify pathophysiologies and pathogenesis through biomolecular imaging and drug interaction mechanisms ・Experiments on the application of biomolecular imaging in drug development ・ Experiments on the molecular imaging of tumors, and brain and heart functions ・Experiments on the discovery of radioactive therapeutic agents and clinical imaging in diagnostic drugs ・ Experiments on bioinorganic chemistry ・ Experiments on the dominant factors of in vivo kinetics and intracellular dynamics in nucleic acid drugs ・ Experiments on the optimization of gene therapy and DNA vaccines ・ Experiments on the uptake mechanisms of macromolecular drugs in macrophage and dendritic cells ・ Experiments on gene function analysis using RNA interference and its applications in treatment ・ Experiments on nucleic acid-based drug delivery ・ Experiments on targeting using medicament carriers ・ Experiments on the statistical analysis of macromolecular pharmaceutical in vivo kinetics ・ Experiments on electrophysiological measurements in drug discovery research for membrane transport proteins ・ Experiments on the physiology of pain and analgesic action mechanisms ・ Experiments on the molecular mechanisms of functional changes in brain plasticity from drug addiction ・ Experiments on activation mechanisms in glial cells ・ Experiments on the analysis of the pathophysiology and pathogenesis of cerebrovascular disease |
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| Evaluation Methods and Policy | Students will be comprehensively evaluated based on their attitude and approach to day-to-day research. | |||
| Course Requirements | None | |||
| Study outside of Class (preparation and review) | ・Students should prepare sufficiently in advance before starting experiments. Once experiments are completed, they should be quick to review and analyze the results of the experiment and give them due consideration, before moving on to the next experiment plan. | |||
| Textbooks | Textbooks/References | Not used | ||
| References, etc. | Others; refer to scientific papers, review articles, and textbooks where appropriate. | |||
