Bioinformatics II: Lead Discovery
| Numbering Code | G-PHA02 61108 LJ86 | Year/Term | 2022 ・ Irregular, First semester | |
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| Number of Credits | 2 | Course Type | Lecture | |
| Target Year | 1st and 2nd year master's students | Target Student | ||
| Language | Japanese | Day/Period | ||
| Instructor name |
DOI MASAO (Institute for Liberal Arts and Sciences Professor) FUTAKI SHIROH (Institute for Chemical Research Professor) TAKAKURA YOSHINOBU (Graduate School of Pharmaceutical Sciences Professor) |
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| Outline and Purpose of the Course | Learning the logic and methodology required for drug discovery lead exploration from multiple perspectives, including gene and genome science, systems biology, bioinformatics, molecular biology, cell biology, neuroscience, developmental biology, and lipid biology. Evaluating the disease state at the molecular level for various diseases, and construct the basis of the drug discovery lead search. When necessary, part-time lecturers from pharmaceutical companies and other organizations give lectures. | |||
| Course Goals |
Understand the fundamentals of logic and methodology required for drug discovery lead exploration. The conditions of various diseases can be explained at the numerator level. Develop the ability to tackle issues (reports) on an independent and continuous basis. |
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| Schedule and Contents |
1st Class Drug Discovery Lead Discovery Theory Introductory Lecture 2nd Class Drug Discovery Lead Search Using Bioinformatics 3rd Class System Biology Approach to Multifactor Diseases 4th Class G Protein-Coupled Receptor-Mediated Signaling and Drug Discovery 5th Class Gene Expression Regulation and Chromatin Remodeling and Drug Discovery 6th Class Calcium Signal Molecular Construction and Drug Discovery 7th Class Structure and Drug Discovery of the Endoplasmic Reticulum Protein Group. 8th Class Physiological Functions and Drug Discovery of Plasma Membrane Lipids 9th Class Membrane Traffic Regulatory Mechanisms and Drug Discovery 10th Class Physiological Functions and Drug Discovery of Lipidomic Signaling 11th Class Regulatory Mechanism of Cell Division and the Molecular Pathogenesis of Carcinogenesis 12th Class Molecular Pathophysiology of Diabetes, Obesity, and Metabolic Syndromes 13th Class Molecular Pathology of Hypertension and Cardiovascular Disease 14th Class Molecular Pathology of Neurogenic Insufficiency and Sleep Disorders 15th Class Future Challenges and Comprehensive Discussion of Drug Discovery Lead Discovery |
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| Evaluation Methods and Policy | Evaluate by attending lectures and submitting reports on issues related to the lecture content. | |||
| Course Requirements | None in particular | |||
| Study outside of Class (preparation and review) | Preparation and review of lecture content using printed and reference books | |||
| Textbooks | Textbooks/References | Printouts will be distributed if otherwise necessary. | ||
| References, etc. | Chikako Tanaka, Ryuichi Kato, 『NEW薬理学』 (Nankodo), Berne / Levy (translation supervised by Takehiko Bando, Shozo Koyama), 『カラー基本生理学』 (Nishimura Shoten), Bruce Alberts et al, 『細胞の分子生物学』 (NEWTON PRESS). Other reference materials will be printed as needed. | |||
