Numbering Code	G-MED41 8S002 LE87	Year/Term	2022 ・ First semester
Number of Credits	4	Course Type	lecture and seminar
Target Year	Doctoral students	Target Student
Language	English	Day/Period	Thu.3・4
Instructor name	MATSUDA FUMIHIKO (Graduate School of Medicine Professor) NAGASAKI MASAO (Center for the Promotion of Interdisciplinary Education and Research Program-Specific Professor)
Outline and Purpose of the Course	This course will be focused on providing the knowledge which are necessary to understand Genomic Medicine. The topics cover from basic genetics and genomics knowledge to novel analytical ways for understanding epigenetics, transcriptomics, proteomics, and metabolomics. The course will be provided as a lecture by expert researcher of each research field.
Course Goals	- Understand the basic concepts behind Genomic Medicine - Learn experimental and statistical ways to analyze genomics and other 'omics data
Schedule and Contents	The course is divided into three major categories (1) Basics of genetics, (2) Next generation sequencing technology, and (3) muiltiple omics approach. Reseachers who are the experts of those topics will give lecture. Three special topics related to human disease genomics, namely, functional genomics, genomics of multigene family, and genomics of artificial intelligence will follow them. Basics of genetics (1) "Human genome and genetic variation" Dr Toru Tezuka Basics of genetics (2) "Mendel's laws, Hardy-Weinberg Equilibrium, and Linkage disequilibrium" Dr Olivier Gervais Basics of genetics (3) "Genetic relatedness and Population stratification" Prof Yoichiro Kamatani Basics of genetics (4) "Genome wide association" Prof Yoichiro Kamatani Next generation sequencing (1) "DNA-seq technology and population level sequencing" Prof Masao Nagasaki Next generation sequencing (2) "DNA-seq technology and rare disorders" Prof Koichiro Higasa Next generation sequencing (3) "ChIP-seq, HiC-seq, ATAC-seq, and single cell sequence" Prof Akira Watanabe Next generation sequencing (4) "RNA-seq technology and analysis" Dr Shuji Kawaguchi Omics approach (1) "Proteomics" Prof Yasushi Ishihama Omics approach (2) "Genome Cohort Study" Prof Fumihiko Matsuda Functional genomics : Prof Shohab Youssefian Special topic "Bioinformatics of Human Genetics" Prof Matthieu Bourgey Special topic "Computation and genetics I" Dr Mario Foglio Special topic "Computation and genetics II" Dr Mario Foglio （to be determined）
Evaluation Methods and Policy	Evaluated by Submission assignments.
Course Requirements	Student needs to have will to make use of genomics and other omics information into clinical medicine in the future.
Study outside of Class (preparation and review)	Required
References, etc.	Human Molecular Genetics 4th Edition　　ISBN:9780815341499