Advanced Course of Bioorganic Chemistry
| Numbering Code | G-AGR07 5GA25 LJ79 | Year/Term | 2022 ・ Intensive, First semester | |
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| Number of Credits | 1 | Course Type | Lecture | |
| Target Year | Target Student | |||
| Language | Japanese | Day/Period | Intensive | |
| Instructor name |
IRIE KAZUHIRO (Graduate School of Agriculture Professor) MURAKAMI KAZUMA (Graduate School of Agriculture Associate Professor) TSUKANO CHIHIRO (Graduate School of Agriculture Associate Professor) |
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| Outline and Purpose of the Course | Lectures on the fundamental of organic chemistry necessary for the quantitative and precise analysis of the relationship between the structure and function of biologically active substances (low molecular weight organic compounds and peptides). As a specific example, the structure-function relationship of the natural product ligand of protein kinase C and the Alzheimer’s etiologic peptide will be explained. | |||
| Course Goals | Ability to discuss structure-function relationships of biologically active substances quantitatively and precisely. | |||
| Schedule and Contents |
Lectures of one or two weeks for following subjects. 1. Energy Theory of Chemical Reaction and Hammett's Law 2. Quantitative structure-function relationship and drug development 3. Solid phase synthesis of peptides and analysis of three-dimensional structure by various instrument analysis methods 4. Toxic conformation of Alzheimer's etiologic peptide amyloid β 5. Exam and feedback (after completing the exam, the answer is distributed and explained) On Monday, 9:30AM-12:00, 5days. |
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| Evaluation Methods and Policy |
[Grading Procedure] Graded by attendance and term exam. [Grading Criteria] Grading criteria and achievement are based on [Grading Criteria and Achievement] described in the “2017 Guide to Degree Program, Graduate School of Agriculture.” |
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| Course Requirements | Prior knowledge of undergraduate level organic chemistry is necessary. | |||
| Study outside of Class (preparation and review) | Review the basics of undergraduate level organic chemistry before taking this course (Textbook: Essential Organic Chemistry, Gakujutsu Tosho Shuppan etc.) | |||
| Textbooks | Textbooks/References | Handouts for reference material. | ||
