Experimental Course of Organic Chemistry in Life Science2
| Numbering Code | G-AGR07 6GC14 EJ79 | Year/Term | 2022 ・ Year-round |
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| Number of Credits | 6 | Course Type | Experiment |
| Target Year | Target Student | ||
| Language | Japanese | Day/Period | |
| Instructor name |
IRIE KAZUHIRO (Graduate School of Agriculture Professor) MURAKAMI KAZUMA (Graduate School of Agriculture Associate Professor) TSUKANO CHIHIRO (Graduate School of Agriculture Associate Professor) |
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| Outline and Purpose of the Course | An organic chemical approach such as synthesis and NMR/MS spectroscopy is quite useful for elucidating various life phenomena. It is most important to identify bioactive compounds and study their mechanism of action in the area of organic chemistry in life science. Our current research mainly focuses on cancer preventive phytochemicals, tumor promoters (natural ligands of protein kinase C), amyloid beta peptides in Alzheimer disease, plant hormones, and antimicrobial compounds. | ||
| Course Goals | Learn the research techniques employed in the field of organic chemistry for life sciences (e.g., organic synthesis, structural determination, measurement of different types of bioactivity), and be able to make observations on research results. | ||
| Schedule and Contents |
1. Purification and analysis of bioactive compounds (e.g., carcinogenic promoters and inhibitors; anti-Alzheimer drugs; substances related to plant hormones; eco-friendly chemicals): separation analysis using chromatography and other methods and high-precision structural analysis of bioactive compounds using chemical and instrumental analysis techniques. 2. Organic chemical analysis of mechanisms of action of bioactive compounds: measurement of in vitro and in vivo measurement of various physiological activities; synthesis of fluorescent or photoactive probes and target identification using such probes for the analysis of mechanism of action; analysis of quantitative structure-activity relationships; chemical synthesis and three-dimensional structural analysis of the functional domains of receptors 3. Synthesis and application of bioactive compounds: development of synthesis methods appropriate for the targeted bioactive compounds; design and synthesis of valuable and related molecules |
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| Evaluation Methods and Policy | Grading will be based on an overall assessment of attendance, research presentations, experiment notes, and commitment to experiments. Refer to '2016 Guide to Degree Programs' for attainment levels of evaluation | ||
| Course Requirements | Completion of Experimental Course Organic Chemistry in Life Science 1 is required. Basic knowledge of organic chemistry. | ||
| Study outside of Class (preparation and review) | Students are expected to study the applicable principles and techniques of research methods employed in the field of organic chemistry for life sciences as they make progress in their experiments. | ||
