Outline of Physiological Chemistry

Numbering Code G-AGR03 8X101 LJ79
G-AGR03 8X101 LJ86
Year/Term 2022 ・ Intensive, Second semester
Number of Credits 2 Course Type Lecture
Target Year Target Student
Language Japanese Day/Period Intensive
Instructor name OGAWA JIYUN (Graduate School of Agriculture Professor)
IRIE KAZUHIRO (Graduate School of Agriculture Professor)
SAKAI YASUYOSHI (Graduate School of Agriculture Professor)
MIYOSHI HIDETO (Graduate School of Agriculture Professor)
KIOKA NORIYUKI (Graduate School of Agriculture Professor)
Sasaki Tsutomu (Graduate School of Agriculture Professor)
TAKESHIMA HIROSHI (Graduate School of Pharmaceutical Sciences Professor)
KAKEYA HIDEAKI (Graduate School of Pharmaceutical Sciences Professor)
OHNO HIROAKI (Graduate School of Pharmaceutical Sciences Professor)
Outline and Purpose of the Course The purpose of the Research Unit for Physiological Chemistry, which was founded in the academic year 2011, is to establish the new academic discipline of physiological chemistry by fusing general physiology and chemical biology, which analyzes life phenomena using chemical techniques and lies at the foundation of the new discipline. This course, Outline of Physiological Chemistry, is now offered based on the research outcomes achieved in the last three years since the founding of the Research Unit.

[Overview and objectives of university-wide educational programs]
 Outline of Physiological Chemistry introduces a broad range of the most current achievements in research that has been made possible by the collaboration between the Graduate School of Agriculture and the Graduate School of Pharmaceutical Sciences, and is an appropriate curriculum for a university-wide graduate program. This course aims to cultivate the future leaders in research who can be immediate assets to the industrial sector.
Course Goals Students will enhance their understanding of recently published studies in the field of physiological chemistry.
Schedule and Contents 1-2 sessions of lectures will be given for each of the following topics:

1. Physiological chemistry related to cardiovascular diseases
 1) Signs of contraction of cardiovascular muscle cells and pharmacology (Hiroshi Takeshima, Atsuhiko Ichimura)
 2) Sensing of extracellular environment and regulation of cellular function at cell membrane (to be announced, Koh Nagata)

2. Physiological chemistry related to aging
 1) The physiological chemistry of redox dynamics and functional compounds (Yasuyoshi Sakai) 
 2) The physiological chemistry of mitochondrial energy metabolism (Hideto Miyoshi, Masatoshi Murai)
 3) The physiological chemistry of β-amyloid and Alzheimer’s disease (Kazuhiro Irie)

3. Physiological chemistry related to the development of functional foods
 1) Mechanism of appetite regulation (Tsutomu Sasaki)
 2) Obesity/energy metabolism and food functionality (Tsuyoshi Goto, Wataru Nomura)
 3) Biological activity of food protein-derived peptides (Ohinata Kousaku)
 4) Food function, food production and microbial function (Jun Ogawa, Akinori Ando)

4. Physiological chemistry related to infection
 1) Search for and development of antifungal seeds (Hideaki Kakeya, Takefumi Kuranaga)
 2) Understanding pharmaceuticals based on chemical structures (Hiroaki Ohno, Shinsuke Inuki)
 3) Chemical synthesis and activity evaluation of natural products such as functional ingredients contained in foods and herbal medicines (Chihiro Tsukano)

Feedback: Instructors will be available to answer questions as needed after the course is completed.
Evaluation Methods and Policy Evaluation will be based on attendance and reports. Refer to '2019 Guide to Degree Programs' for attainment levels of evaluation.
Course Requirements Basic knowledge of biochemistry, organic chemistry, and molecular biology is required.
Study outside of Class (preparation and review) Go through important research papers in the field of physiological chemistry before the course.
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