Applied Life Sciences I
| Numbering Code | G-AGR03 5CA01 LJ79 | Year/Term | 2022 ・ Intensive, First semester | |
|---|---|---|---|---|
| Number of Credits | 1 | Course Type | Lecture | |
| Target Year | Target Student | |||
| Language | Japanese | Day/Period | Intensive | |
| Instructor name |
MIYOSHI HIDETO (Graduate School of Agriculture Professor) SHIRAI OSAMU (Graduate School of Agriculture Professor) |
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| Outline and Purpose of the Course | This course consists of three parts. The first part covers the statistical treatment in science, the fundamental concept of chemical equilibrium governed by entropy, and the linear free energy relationship. The second part deals with the fine protein structure aimed at X-ray structure determination. The third part focuses “Green Chemistry”. “Green Chemistry” is an important concept in recent chemical laboratories and enterprises. Using a literature “Green Chemistry for Chemical Synthesis (Trost et al. PNAS, vol. 105, 13197-13202, 2008)” as a text, we will study practical importance and many examples of Green Chemistry. | |||
| Course Goals | This course will provides students with an opportunity to review their knowledge of organic chemistry, protein chemistry, and physicochemistry that they learned in their undergraduate studies, and to acquire the knowledge necessary to advance their graduate studies and research. | |||
| Schedule and Contents |
Sessions 1 to 5 (Instructor: Miyoshi) “Green Chemistry,” which aims to minimize the environmental impact of chemistry research and industry, is even more important than it has been in the past. In this course, Green Chemistry for Chemical Synthesis by Professor Trost of Stanford University will be used as a textbook, and students will learn the importance of practicing green chemistry and its specific examples. Session 1: Twelve principles of Green Chemistry Sessions 2 to 4: An example of organic reactions aimed at atom economy Session 5: Reconsideration of “solvents” used in manufacturing processes Sessions 6 to 10: (Instructor: Mikami) The objective of these lectures is to provide students with an accurate understanding of the structures and functions of proteins. Students will assemble the molecular models of proteins in order to understand the secondary and tertiary structures of proteins. Session 6: Chemical structures of amino acid, peptide, and protein. The chemical structures and physiochemical structures of amino acid, peptide, and protein will be discussed. Sessions 7 to 8: Protein secondary structure It is difficult to understand the three-dimensional structure of protein solely by looking at the diagrams of two-dimensional structure of protein shown in textbooks and reference books. The sessions will provide each student an opportunity to gain a correct understanding of protein secondary structure by assembling molecular models. Session 9: Protein tertiary structures The classification of protein tertiary structures and the computer graphics of the structures will be discussed. In addition, we will also introduce the methods of determining the three-dimensional structure of protein. Session 10: Students will work independently to illustrate protein using computer graphics. Sessions 11 to 15: (Instructor: Kano) The sessions will review the basic principles of physicochemistry by focusing on a number of topics while providing students with essential concepts for conducting experiments. Quizzes will be given during class. Sessions 11 to 13: Brownian motion and theory of errors Students will consider why Brownian motion occurs, learn about Einstein’s Random Walk, connect the concepts to statistics, study approaches to errors, and learn the basic techniques for handling numerical values. Session 14: Equilibrium and entropy Students will examine the pros and cons of the law of mass action, and understand that entropy is the essence of chemical equilibrium. Session 15: Linear free-energy relationship The concept of linear free-energy relationship, which connects equilibrium to speed, is a very important concept for studying chemistry, as exemplified by Hammett’s rule. Students will review this concept and learn the meaning of the rate constant and the catalyst process. Feedback: Instructor is available to meet with students individually if they have any questions about the course. This course will be offered on three Mondays (3rd to 5th period) |
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| Evaluation Methods and Policy | While evaluation will be based on reports and attendance, the student’s attitude in class will also be comprehensively considered. | |||
| Course Requirements | None. | |||
| Study outside of Class (preparation and review) | Students are expected to collect materials on topics assigned in class and review them independently. | |||
| Textbooks | Textbooks/References |
Green chemistry for chemical synthesis, Proc., Li, C.-J. and Trost B. M., In Professor Miyoshi’s class, the following publication will be used as textbook. Please print it out and read it before class. |
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