Chemistry of Bioregulation
| Numbering Code | G-AGR03 6CA09 LJ79 | Year/Term | 2022 ・ Intensive, Second semester |
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| Number of Credits | 1 | Course Type | Lecture |
| Target Year | 2nd year master's students | Target Student | |
| Language | Japanese | Day/Period | Intensive |
| Instructor name |
MIYAGAWA HISASHI (Graduate School of Agriculture Professor) MIYASHITA MASAHIRO (Graduate School of Agriculture Associate Professor) |
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| Outline and Purpose of the Course | Many small organic molecules have been utilized as medical drugs and pesticides, because of their regulatory activity toward the biological processes of living organisms. Theory and practice of rational molecular design of biologically active compounds are outlined, mentioning how the recent advances in biochemistry and molecular biology can be applied for that | ||
| Course Goals |
1) To understand how the structure and the physicochemical property of a molecule affect its biological activity. 2) To understand basic theories and methods of syntheses and analysis of peptide compounds. |
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| Schedule and Contents |
1) search and design of drugs: overview 2) random screening and rational design 3) quantitative structure-activity relationship of biologically active compounds 4) analytical techniques for the research of biologically active peptides 5) mass spectrometry-based structure analysis and chemical synthesis of peptides 6) application of biologically active peptides and molecular design of non-peptide active compounds 7) sum up and test |
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| Evaluation Methods and Policy | Class participation 35%, examination 65%. Refer to '2019 Guide to Degree Programs' for attainment levels of evaluation | ||
| Course Requirements | Basics of organic chemistry and biochemistry are to be mastered. | ||
| Study outside of Class (preparation and review) | No specific preparations are required for the class, but a constant interest in the chemical structures of biologically active compounds is helpful to understand the lecture. After the class, the review of each topic explained in the class by referring to the relevant parts in the specified reference books is requested. | ||
| References, etc. |
An Introduction to Medicinal Chemistry, Patrick, (Oxford) Practice of Medicinal Chemistry, Wermuth (Ed.), (Academic Press) Mass spectrometry (Japanese translation), Gross, (Springer Japan) |
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