Laboratory Practice in Basic Fine Organic Synthesis
| Numbering Code | G-PHA01 74209 PJ86 | Year/Term | 2022 ・ Irregular, year-round | |
|---|---|---|---|---|
| Number of Credits | 1 | Course Type | Practical training | |
| Target Year | 1st and 2nd year master's students | Target Student | ||
| Language | Japanese | Day/Period | ||
| Instructor name |
OHMIYA HIROHISA (Institute for Chemical Research Professor) YOSHIHIRO UEDA (Institute for Chemical Research Assistant Professor) |
|||
| Outline and Purpose of the Course |
(Aim) This course aims to familiarize students with the basic experiment methods, principles, and teaching methods of organic synthetic chemistry, instrumental analysis, molecular recognition, and computational chemistry. (Summary) After learning about experiment safety and legal compliance obligations in the research environment, students will endeavor to learn about handling organic compounds and organometallic compounds, synthesis, separation and refinement processes, structural analysis, functional analysis, the principles and experiment methods of theoretical calculations, and their teaching methods. |
|||
| Course Goals |
(1) Design of synthetic pathways and the synthetic operation of compounds. (2) Structural analysis and physical property analysis of target molecules. (3) Safe handling of explosive compounds, water-reactive compounds, and unstable compounds. (4) Measurements of association constants and analysis of association state. (5) Evaluation of stable conformation through theoretical calculations and proposal of reactive transition states. |
|||
| Schedule and Contents |
1-15: The following practical training will be held: Safety classes Students will learn about safety during experiment operation and in the laboratory, how to handle chemicals, and legal compliance obligations in the research environment. Experiment methods in organic synthetic chemistry Students will learn about basic operations in organic synthesis, the separation and refinement process of organic compounds, and the handling of water-reactive compounds, oxygen-reactive compounds, organometallic compounds, and toxic compounds, as well as associated teaching methods. Experiment methods for instrumental analysis Students will undergo practical training in the measurement and analysis of NMR spectra, ultraviolet absorption spectra, CD spectra, mass spectra, infrared spectra, and fluorescence spectra. They will also learn analytical methods that use high-performance liquid chromatography and gas chromatography, alongside analysis of optically active compounds, how to handle them, and associated teaching methods. Experiment methods for molecular recognition research Students will learn how to evaluate association constants using ultraviolet absorption spectra, how to evaluate association constants using NMR spectra, and how to evaluate association constants using trace calorific value measurements, as well as associated teaching methods. Computational chemistry Students will learn molecular modeling through the molecular force field method and the molecular orbital method, as well as reaction transition state analysis and associated teaching methods. Presentations and discussion of practical training results Presentations and discussion of practical training results related to organic synthetic chemistry, molecular recognition, and computational chemistry |
|||
| Evaluation Methods and Policy | Students will be comprehensively evaluated based on their approach to practical training, their proficiency in practical training, and the appropriateness of their teaching methods. | |||
| Course Requirements | None | |||
| Study outside of Class (preparation and review) |
Before experimenting with the safety, toxicity, and physical properties of compounds, students should ensure they have sufficiently informed themselves using MSDS, the Merck Index, and the Dangerous Goods Handbook. Students should participate in computational chemistry seminars that will be hosted where appropriate. |
|||
| Textbooks | Textbooks/References | Others; safety seminar printouts and experimental chemistry lectures | ||
| References, etc. | Others; technical books on organic synthesis and instrumental analysis, and equipment usage manuals | |||
