京都大学 京都大学

Molecular Embryology in Mammals

Numbering Code G-AGR04 5DA43 LJ84 Year/Term 2022 ・ First semester
Number of Credits 2 Course Type Lecture
Target Year Target Student
Language Japanese Day/Period Thu.2
Instructor name MINAMI NAOJIROU (Graduate School of Agriculture Professor)
Outline and Purpose of the Course This course introduces the molecular mechanisms of germ cell and preimplantation embryo development in mammals, and epigenetic mechanisms of gene expression in development are reviewed. All participants will present related topics published in scientific paper.
Course Goals 　By learning about the formation process and functions of germ cells, the essence of life in all mammals, students will gain an understanding of life phenomena that occur at the molecular level in the early development stage, which begins with fertilization.
Schedule and Contents 　This course will cover the following topics to help students understand the molecular mechanisms of the early development of mammals. Students will be asked to introduce research papers related to one of the topics below, and the student audience will join in to discuss each presentation.

Session 1: Overview of Molecular Embryology in Mammals and course outline
Session 2: Molecular mechanisms of epigenetics
Session 3: Egg development and genome imprinting
Session 4: DNA methylation and ontogeny in the germline
Session 5: Meiosis and epigenetics
Session 6: Molecular mechanisms of egg meiosis (1): Characteristics of egg meiosis
Session 7: Molecular mechanisms of egg meiosis (2): meiosis arrest and resumption
Session 8: Changes to egg nucleus phase and chromosome dynamics
Session 9: Gene expression program before and after fertilization
Session 10: Structural changes in the molecules related to fertilization and male and female genomes
Session 11: Molecular mechanisms of zygotic genome activation: maternal-to-zygotic transition and histone modifications
Session 12: Zygotic genome activation and epigenetic modifications
Session 13: Factors that control zygotic genome activation
Session 14: Genetic engineering for explaining the molecular mechanisms of early development
Session 15: Feedback

　Several university professors and researchers will be invited as guest lecturers to give lectures on research related to the above topics, and students will participate in discussions following the presentations.
Evaluation Methods and Policy Grading will be based on participation in class discussions and presentation of research papers.

Refer to '2017 Guide to Degree Programs' for attainment levels of evaluation
Course Requirements Basic knowledge of molecular, cellular and reproductive biology.
Study outside of Class (preparation and review) Students are expected to read assigned research papers in advance and prepare materials for their class presentation.
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