生物化学III(分子生物学)【H30以降入学者用】

Numbering Code U-PHA00 2C214 LJ86 Year/Term 2021 ・ Second semester
Number of Credits 2 Course Type Lecture
Target Year 2nd & 3rd year students Target Student
Language Japanese Day/Period Thu.1
Instructor name KIMURA IKUO (Graduate School of Biostudies Professor)
Outline and Purpose of the Course Explain the following concepts related to the structure and function of nucleic acids, which are the chemical basis of gene signaling.
Course Goals 1. Explain the structure and function of nucleic acids.
2. Explain genes and chromosomes.
3. Explain the biosynthesis of DNA, RNA, and proteins.
4. Explain the gene-expression process.
5. Explain the gene-expression-regulation mechanism.
6. Explain the basic technology of genetic modification.
Schedule and Contents 1. Introduction: History of nucleic-acid research
2. Nucleotides and nucleic acids: Types, structures and properties of nucleotides and nucleic acids (DNA, RNA)
3. Genes and chromosomes (1): Chromosome components
4. Genes and chromosomes (2): Structure of genes and chromosomes
5. DNA metabolism (1): DNA replication
6. DNA metabolism (2): DNA mutation and repair
7. DNA metabolism (3): DNA recombination
8. RNA metabolism (1): Transcription from DNA to RNA
9. RNA metabolism (2): RNA processing
10. Protein metabolism (1): Translation from RNA to protein
11. Protein metabolism (2): Post-translational maturation and degradation of proteins
12. Gene-expression regulation (1): The principle of gene-expression regulation
13. Gene-expression regulation (2): The gene-expression-regulation mechanism in bacteria
14. Gene expression regulation (3): The gene expression regulation mechanism in eukaryotes
15. Basics of genetic-engineering technology
Evaluation Methods and Policy The evaluation will be based on regular written tests, taking into account whether students can discuss nucleic acids, genes, chromosomes, the metabolism of DNA, RNA, and proteins, the gene-expression-regulation mechanism, and the basic technology of DNA recombination in relation to molecular biology, as described in the attainment targets.
Course Requirements This course assumes a basic knowledge of biochemistry, and students must therefore have already taken Biochemistry I and II.
Study outside of Class (preparation and review) Lecture printouts will be distributed in advance, so please read them and resolve any doubts you may have about the content. Also, be sure to review the material in order to retain the knowledge of what you have learned.
Textbooks Textbooks/References Other, printed handout
References, etc. 『Principles of Biochemistry』 (Worth Publishers), 『レーニンジャーの新生化学(第7版)』 (Hirokawa Shoten)
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