ILAS Seminar-E2

Numbering Code U-LAS70 10002 SE50 Year/Term 2021 ・ Second semester
Number of Credits 2 Course Type seminar
Target Year Mainly 1st year students Target Student For all majors
Language English Day/Period Wed.5
Instructor name RAUDZUS,Fabian (Graduate School of Medicine Assistant Professor)
Outline and Purpose of the Course The seminar “Disorders of the Nervous System” introduces the causes of and therapies for different diseases resulting from neurodegeneration, the environment, genetics, or injury. These diseases are not only a burden for the affected person, but also for the relatives as well as society. For most of these diseases, no cure is yet available and, therefore, it is crucial to understand the underlying mechanisms to discover novel approaches. The seminar will therefore introduce the peripheral and central nervous systems and the organization of the human brain, and lead to a discussion of the genetic and environmental bases for these disorders. Subsequent seminars will focus first on neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and then on disorders of the peripheral nervous system, especially the loss of sight and hearing. The seminars will be highly interactive: short presentation of topics by students will be extended to group discussions. After the background to and causes of a disorder are discussed, each student will get the chance to work on selected literature to gain deeper insights into various current treatments and future perspectives.
Course Goals The seminar will introduce you to common disorders of the nervous system. The necessary knowledge gained will enable you to understand current research progress in this field. By guided personal study of the primary literature, you will also gain further insights into current treatments and different methodologies. After finishing the seminar, you will be familiar with a large repertoire of skills that will enable you to understand, discuss, and evaluate disorders of the nervous system and their treatment.
Schedule and Contents 1. Introduction into the peripheral and central nervous systems
2. Organization and function of the human brain
3. Genetic causes of diseases of the nervous system
4. Environmental causes of disorders of the nervous system
5. How Alzheimer's disease slowly destroys memory and thinking skills
6. Tremor, slowed movement, and rigid muscles: Parkinson's disease
7. Huntington's Disease: a progressive brain disorder with early-onset
8. Neurodegeneration due to misfolded proteins: Prion disease, Creutzfeldt-Jakob disease
9. Degeneration of the peripheral nervous system: example of Charcot-Marie-Tooth disease
10. Spinal cord injuries: what happens when the connection between brain and peripheral nervous system is damaged or destroyed?
11. Disorders of the brain due to excessive neuronal activity: Epilepsy
12. Diseases of the visual system: Glaucoma
13. Sensorineural hearing loss: Brown-Vialetto-Van Laer syndrome
14. Disorders caused by inflammation: Guillain-Barré syndrome
15. Exam
16. Feedback
Evaluation Methods and Policy Class/video meeting attendance and active participation: 20%
Assessments and presentations: 40%
Final assesment: 40%
Course Requirements The course is open to all students but a basic understanding in biology is recommended. In addition, it is recommended to attend the seminar "Physiological Neuroscience" to get introduced into the basic principles of neuroscience.
Study outside of Class (preparation and review) Preparation and review is strongly recommended for every seminar.
Textbooks Textbooks/References Neuroscience: Exploring the Brain, Mark F. Bear, Barry W. Connors, Michael A. Paradiso, (Jones & Bartlett Learning), ISBN:9781284211283, Enhanced 4th Edition (English Edition)
purchasing is not mandatory but is very helpful for the preparation and revision of the classes