Principles of Genetics-E2

Numbering Code U-LAS14 20029 LE68 Year/Term 2021 ・ First semester
Number of Credits 2 Course Type Lecture
Target Year Mainly 1st & 2nd year students Target Student For science students
Language English Day/Period Tue.2
Instructor name Shohab YOUSSEFIAN (Graduate School of Medicine Professor)
Outline and Purpose of the Course Genetics is the science of heredity and seeks to explain variation between related organisms at the genetic and molecular levels. All aspects of life are affected by the expression of genes, and as our knowledge of genomes and genes increases, we will begin to apply classical and molecular genetic information to various microbial, plant, animal and medical studies. In turn, such studies will help us understand how normal developmental events are regulated by genes, and how mutations and aberrations in genes and chromosomes can lead to various genetic diseases.
The course thus begins by considering the basic concepts of inheritance, i.e. how Mendelian traits are passed to the next generation; it will then outline our current understanding of chromosomes, DNA and genes and their regulation, and will finally examine how such genes can control normal developmental events in organisms, whereas aberrant control of genes can lead to developmental failure and cancer.
Course Goals To acquire a basic understanding of the principles of classical and molecular genetics and their relevance and application to modern biological sciences, especially development and cancer.
Schedule and Contents Main Topics:
1. Development of modern genetics
2. Cells and cell division
3. Mendelian inheritance of traits
4. Extensions of Mendelian genetics
5. Chromosomes and chromosome aberrations
6. Genomes, DNA structure and replication
7. Gene expression and regulation
8. DNA mutations and repair
9. Developmental genetics I
10. Developmental genetics II
11. Cancer genetics I
12. Cancer genetics II
13. Final Exam
14. Feedback

Please note that these 12 lecture subjects will cover the complete 14 lecture course of the series.
Evaluation Methods and Policy Evaluation will be based on class attendance and active participation (~25 %), quizzes (~30 %), other assignments (5 %), and a final assignment/examination (~40 %).
Course Requirements None
Study outside of Class (preparation and review) Whether these lectures are presented as face-to-face classes or, because of COVID-19, as online classes, the general structure and format will the same form of FLIP lectures. Here, on-demand videos and handouts for each lecture will be uploaded on PandA one week before each class so that students have time to go through them carefully. These videos will include full explanations of the materials as well as other visual tools such as animations and videos that will help better explain the concepts. Then, during each weekly face-to-face (or on-line) class, we will discuss the concepts presented in the videos, with each student explaining their answers to various thought-provoking questions, thereby developing deeper insights into the materials. On-line forums will be opened after the class to allow students to discuss areas that are still unclear or to upload videos that better explain certain issues. Quizzes throughout the semester will challenge the understanding and learning of the various concepts.
Textbooks Textbooks/References Concepts of Genetics 10th Edition 2012, Klug, Cummings, Spencer, Palladino, (Pearson), ISBN:978-0-321-72412-0, Few copies are available in the Medical School Library