Supramolecular Chemistry

Numbering Code G-ENG15 6D837 LJ61
G-ENG16 6D837 LJ61
Year/Term 2021 ・ Second semester
Number of Credits 2 Course Type Lecture
Target Year Target Student
Language English Day/Period Tue.4
Instructor name Juha Lintuluoto (Graduate School of Engineering Associate Professor)
LANDENBERGER, Kira Beth (Graduate School of Engineering Senior Lecturer)
Outline and Purpose of the Course This course is open to all master and doctoral engineering students. The aim is to enhance students’ knowledge of non-covalent molecular interactions found in both synthetic and natural chemical compounds and materials. Additionally, students learn how to choose methods to study and observe non-covalent molecular interactions, and how to measure and evaluate them quantitatively. Throughout the course feedback will be given by instructors. The course will also improve students to gain confidence in studying English of supramolecular topics. The course contents are suitable for a wide variety of chemistry students.

Course Goals Understanding the nature and types of supramolecular interactions, and applying them into various chemical, biological and other materials applications.  
Schedule and Contents 1. Course Introduction & Interactions and methods in Supramolecular Chemistry: Non covalent interactions (H-bonding, pi-pi; lone-pairs and metals, ionic), spectrometric methods (NMR, UV-vis, Fluorescence, CD, Mass) Oct. 5

2. Binding Constants, Cooperativity, Complementarity, Preorganization Equilibrium systems, enthalpy and entropy upon binding, quantitative analysis Oct.12

3. Cation Binding with Current Examples Cation binding, binding into anionic host molecules and neutral host molecules Oct.19

4. Anion Binding with Current Examples Anion binding, binding into cationic host molecules, and neutral host molecules Oct. 26

5. Neutral molecule binding and Self-Assembly with Current Examples Neutral molecule binding into neutral or charged host molecules, self-binding molecules Nov.2

6. Supramolecular Devices, Sensors and Catalysis with Current Examples Electron transfer, energy transfer, information transfer in supramolecules Nov. 9

7. Crystal Engineering I: Crystal engineering, crystal classes, crystal nucleation and growth, commonly found intermolecular interactions Nov. 16

8. Crystal Engineering II: Polymorphism, hydrates and solvates, cocrystals, crystal structure prediction Nov. 30

9. Network Solids: Zeolites, intercalates, coordination polymers (e.g. MOFs) Dec.7

10. Solid State Inclusion Compounds I: Clathrates (structures and applications), podands, cyclophanes, etc. Dec. 14

11. Solid State Inclusion Compounds II: Cucurbiturils, cyclodextrins, cryptophands, etc. Dec. 21

12. Microcalorimetry Isothermal titration calorimetry to analyze binding thermodynamics of biomolecules.
Differential scanning calorimetry to analyze folding thermodynamics of proteins. Nov.16* Lecturer Prof. Oda, Kyoto Prefectural University Dec. 28
13. Supramolecular Liquid Crystals: Nature and structure of liquid crystals, applications and design, polymeric liquid crystals Jan. 11

14. Supramolecular Polymers, Gels and Fibers: Supramolecular polymer structure and design, properties, kinetics and reaction mechanics of supramolecular polymers, applications Jan.18
Evaluation Methods and Policy Evaluation: 20% participation (engaging the classes and activity), 80% reports.
*More than 3 unexcused absence can result in course failure.
Course Requirements Active engagement in lectures, which provide basis for the reports required in this course. Each student is required to submit 4 chosen reports on any given topics during the course. However, 2 reports each should be submitted for the given topics on lectures 1-6 and 8-14, excluding lecture 12.

If you have any concerns or questions regarding the course, please do not hesitate to contact (075)- 383-7065 or landenberger.kirabeth.2x at or (075)-383-2876 or lintuluoto.juhamikael.7u at .

Study outside of Class (preparation and review) Students should fulfill the report tasks out of class time (home work).