Advanced Methods in Systems

Numbering Code G-PHA02 75501 SJ86 Year/Term 2021 ・ Irregular, year-round
Number of Credits 2 Course Type Seminar
Target Year 1st and 2nd year master's students Target Student
Language Japanese Day/Period
Instructor name OHNO HIROAKI (Graduate School of Pharmaceutical Sciences Professor)
KAKEYA HIDEAKI (Graduate School of Pharmaceutical Sciences Professor)
DOI MASAO (Institute for Liberal Arts and Sciences Professor)
HIRASAWA AKIRA (Graduate School of Pharmaceutical Sciences Associate Professor)
HATTORI AKIRA (Graduate School of Pharmaceutical Sciences Associate Professor)
INUKI SHINSUKE (Graduate School of Pharmaceutical Sciences Associate Professor)
YAMAGUCHI YOSHIAKI (Graduate School of Pharmaceutical Sciences Senior Lecturer)
Outline and Purpose of the Course In this course, students will create and publish content, such as web apps and programs, in the fields of systems biology and drug discovery.
Course Goals Students will study research, gain a comprehensive understanding, and create content on the following: Ligand search research for pharmacological evaluations using comprehensive analysis technologies, application in drug discovery of G protein-coupled receptors, receptor function analysis, the 3D structure and action mechanisms of receptor proteins, the molecular recognition mechanisms of drug receptors, mammalian biorhythms, timed drug discovery research, the multilayer molecular network systems of mammalian biorhythms, advanced chemical biology of chemotherapy, system chemotherapy utilizing chemoinformatics and bioinformatics, the production of useful substances through genetic engineering methods, the molecular design and chemical synthesis technology of drug leads, evaluation systems for drug candidate compounds, and natural products chemistry and natural products pharmaceutical sciences of new biologically active substances.
Schedule and Contents Each subject is scheduled to account for 2 weeks of classes:

・ Produce content relating to pharmacological evaluations using comprehensive analysis technologies (Akira Hirasawa)
・ Produce content relating to Ligand search technology (Akira Hirasawa)
・ Produce content relating to applications in drug discovery of G protein-coupled receptors (Akira Hirasawa)
・ Produce content relating to receptor function analysis (Akira Hirasawa)
・ Produce content relating to the 3D structure and action mechanisms of receptor proteins (Shinya Oishi)
・ Produce content relating to the molecular recognition mechanisms of drug receptors (Akira Hattori)
・ Produce content relating to mammalian biorhythms (Masao Doi)
・ Produce content relating to timed drug discovery research (Masao Doi)
・ Produce content relating to multilayer molecular network systems of mammalian biorhythms (Yoshiaki Yamaguchi)
・ Produce content relating to advanced chemical biology research on chemotherapy (Hideyaki Kakeya)
・ Produce content on system chemotherapy utilizing chemo- and bioinformatics (Hideyaki Kakeya)
・ Produce content relating to the production of useful substances through genetic engineering methods (Hiroaki Ohno)
・ Produce content relating to the molecular design and chemical synthesis technologies of drug leads (Hiroaki Ohno)
・ Produce content relating to evaluation systems for drug candidate compounds (Hiroaki Ohno)
・ Produce content relating to the natural products chemistry and natural products pharmaceutical sciences of new bioactive substances (Hideyaki Kakeya)
Evaluation Methods and Policy Students will be comprehensively evaluated based on subject reports. Evaluation may also be based on class attendance and practice.
Course Requirements None
Study outside of Class (preparation and review) Students should search for information about systems biology and drug discovery in past papers from relevant fields and across the Internet.
Textbooks Textbooks/References Others; printouts will be distributed where appropriate.
References, etc. Others; may be specified according to seminar content.
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