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143 - iCeMS Learning Lounge #6: Akihisa Yamamoto + Georgia Kafer, 2015

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iCeMS Learning Lounge #6

March 31, 2016

2nd floor Seminar Room, iCeMS Main Building, Kyoto University

Dr. Akihisa Yamamoto
iCeMS Motomu Tanaka Lab
Dr. Georgia Kafer
iCeMS Peter Carlton Lab

iCeMS page
Video

Course Description

Why Our Science Matters
The "Learning Lounge" features young scientists who, in 20 minutes deliver a presentation that will persuade any curious listener, even those without a scientific background, why their research area -- not just the personal research of the speaker -- is important to the world.


Dr. Akihisa Yamamoto
Sticky Moments in Biology


Cells are the basic building blocks within our body, and they are bound together with a kind of 'glue'. When this glue disappears, tissue is destroyed, and serious illness, such as cancer metastasis, occurs. Knowing stickiness may help to recognize which cells are most likely to be healthy or not. I will introduce our physical techniques to directly measure 'stickiness' that allows us to characterize them.

Cell adhesion is an important factor to understand how tissues and organs are constructed in living organisms. By quantitatively measuring how the adhesion strength varies over different cell species and states, we are able to understand the mechanism of tissue destruction caused by diseases, and to create novel methodologies to find the first signs of diseases. We aim to study unique phenomena that span physics, biology and medical science.

Dr. Georgia Kafer
Protecting Your DNA Code


The human instruction "manual" is written in a specialized biological code commonly referred to as "DNA". If the DNA is damaged then parts of the code can be lost or misinterpreted which is likely to result in diseases. DNA can be damaged by sources external to the body, but is more commonly damaged by internal "everyday" biological processes. I will discuss our research that investigates how DNA damaged is repaired.

Of all the research projects I have worked on so far, my current project studying DNA damage has been the most enjoyable for me. This is because of the beauty that lies in how a cell responds to DNA damage in such a highly organised, yet fascinatingly complex way. It’s also surprising that despite this field of research beginning in the 1940’s we still know relatively little about it. And do you know what is really exciting? Any new knowledge about DNA damage has the potential to directly impact how we view, treat and prevent a huge range of human diseases.